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A.C.E. mixture (or ACE mixture) is a historical anaesthetic agent for general anaesthesia, which was first suggested by Dr. George Harley and first used in England around 1860, and in 1864 it was recommended for use by the Royal Medical and Surgical Society’s Chloroform Committee. However it was used rarely after the 19th century, although used for slightly longer in Germany. It was a mixture of alcohol, chloroform and ether (diethyl ether)〔 which gives the mixture its name. Its actions were said to be between that of chloroform and ether and it was used as a good substitute when ether alone was contraindicated.〔 Its boiling point was given as °C and it was measured in Drachm. ==Usage== A.C.E. mixture was most commonly made up in the ratio: 1 part alcohol, 2 parts chloroform, and 3 parts ether〔 although other ratios existed. See 'other preparations' below. Chloroform (which was first used in 1847) used on its own produces myocardial depression, however the excitatory properties of the alcohol and ether contained with the choloroform in the A.C.E. mixture was believed to reduce this.〔 However, some did question this experimentally at the time. Many anaesthetists favoured A.C.E. mixture and one author in 1887 in the British Medical Journal considers the A.C.E. mixture, at the time, the best anaesthetic for general use and use in childbirth. He states one downside; the "excited" state of patients on regaining consciousness after the anaesthetic, due to the alcohol in the mixture. Another downside of the mixture, as with most anaesthetics at the time, was its high flammability. Deaths have been known to occur from the mixture.〔 However, at the time, deaths from A.C.E. mixture were reported less in number than the deaths from chloroform or ether.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「A.C.E. mixture」の詳細全文を読む スポンサード リンク
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